Browsing Cannabinoid Science

Does CBD interact with the CB1 receptor site?
New data indicates that CBD interacts directly with the CB1 receptor site in ways that are therapeutically relevant. CBD parks at a different docking site on the CB1 that is functionally distinct from THC’s orthosteric binding site. When docked, it influences how the receptor responds to stimulation by THC and the endogenous cannabinoids. This can have a dramatic impact on the efficiency of cell signaling. Click here to learn more. MANTIS_RECOMMEND = { property: '53422cdc8e92f89afbf09d5f', render: 'mantis__recommended__wordpress' }; var z = document.createElement("script"); z.type = "text/javascript"; z.async = true; z.src = "//static.mantis.marketing/recommend.min.js"; var s …
What is the transient receptor potential vanilloid-type one (TRPV1)?
A third receptor that gets little attention is TRPV1 (transient receptor potential vanilloid-type one). The function of TRPV1 is to detect and regulate body temperature. In addition, TRPV1 is responsible for the sensations of extreme external heat and pain and is subject to desensitization. Therefore, if continuously stimulated, the pathway will eventually slow down or even stop. This raises therapeutic possibilities for agents to effectively treat certain kinds of neuropathic pain. Click here to learn more. MANTIS_RECOMMEND = { property: '53422cdc8e92f89afbf09d5f', render: 'mantis__recommended__wordpress' }; var z = document.createElement("script"); z.type = "text/javascript"; z.async = …
What is the CB2 receptor?
CB2 is primarily associated with the immune system and found outside of the brain in such places as the gut, spleen, liver, heart, kidneys, bones, blood vessels, lymph cells, endocrine glands and reproductive organs. CBD is keyed to CB2. Until recently, this receptor site was thought only to be responsible for anti-inflammatory and therapeutic effects, playing no role with nerve cells or bundles. However, studies now show that it also plays an important role in the signal processing of the brain. Click here to learn more. MANTIS_RECOMMEND = { property: '53422cdc8e92f89afbf09d5f', render: 'mantis__recommended__wordpress' }; var z …
What is the CB1 receptor?
CB1 is predominantly located in the nervous system, connective tissues, gonads, glands, and organs. CB1 is not found in the medulla oblongata (the part of the brain stem responsible for respiratory and cardiovascular functions). Current research shows that THC is specially keyed to the CB1 receptor site, making it responsible for the euphoric effects most associated with cannabis. When THC is present in the CB1, feelings of pain are reduced. Click here to learn more. MANTIS_RECOMMEND = { property: '53422cdc8e92f89afbf09d5f', render: 'mantis__recommended__wordpress' }; var z = document.createElement("script"); z.type = "text/javascript"; z.async = true; z.src …
Are there different kinds of cannabinoids?
The primary cannabinoid receptors are identified as Cannabinoid type 1 receptors (CB1-R) and Cannabinoid type 2 receptors (CB2-R). The receptors can be “unlocked” by three kinds of cannabinoids: Endocannabinoids – endogenous-fatty-acid cannabinoids produced naturally in the body (e.g., anandamide and 2-AG); Phytocannabinoids – concentrated in the oily resin of the buds and leaves of plants such as cannabis (e.g., THC and CBD); and Synthetic cannabinoids – manufactured by artificial means such as in a laboratory. Click here to learn more. MANTIS_RECOMMEND = { property: '53422cdc8e92f89afbf09d5f', render: 'mantis__recommended__wordpress' }; …
Where are CB2 receptors located in the human body?
Cannabinoid receptors are located throughout the body. CB2 receptors are primarily associated with the immune system and found outside of the brain in such places as the gut, spleen, liver, heart, kidneys, bones, blood vessels, lymph cells, endocrine glands and reproductive organs. Click here to learn more. MANTIS_RECOMMEND = { property: '53422cdc8e92f89afbf09d5f', render: 'mantis__recommended__wordpress' }; var z = document.createElement("script"); z.type = "text/javascript"; z.async = true; z.src = "//static.mantis.marketing/recommend.min.js"; var s = document.getElementsByTagName('head')[0]; s.parentNode.insertBefore(z, s); …
Where are CB1 receptors located in the human body?
Cannabinoid receptors are located throughout the body. CB1 receptors were first detected in the brain, but science now shows that CB1-R are also located in many other organs, connective tissues, gonads and glands. They are not found in the medulla oblongata (the part of the brain stem responsible for respiratory and cardiovascular functions). Click here to learn more. MANTIS_RECOMMEND = { property: '53422cdc8e92f89afbf09d5f', render: 'mantis__recommended__wordpress' }; var z = document.createElement("script"); z.type = "text/javascript"; z.async = true; z.src = "//static.mantis.marketing/recommend.min.js"; var s = document.getElementsByTagName('head')[0]; s.parentNode.insertBefore(z, s); …
What is clinical endocannabinoid deficiency (CEDC)?
Clinical endocannabinoid deficiency (CEDC) is a proposed spectrum disorder that has been implicated in a range of illnesses, including fibromyalgia, migraine and irritable bowel syndrome. So far, very little research has been conducted on this speculative disorder, but if it is found to exist, it could be responsible for these very common conditions and may respond favorably to cannabinoid therapies. Click here to learn more. MANTIS_RECOMMEND = { property: '53422cdc8e92f89afbf09d5f', render: 'mantis__recommended__wordpress' }; var z = document.createElement("script"); z.type = "text/javascript"; z.async = true; z.src = "//static.mantis.marketing/recommend.min.js"; var s = document.getElementsByTagName('head')[0]; s.parentNode.insertBefore(z, s); …
What is signal transduction?
When a specific cannabinoid or combination of cannabinoids bind to a specialized receptor, an event or a series of events is triggered in the cell, resulting in a change in the cell’s activity, its gene regulation or the signals that it sends to neighboring cells. This process is called “signal transduction.” Click here to learn more. MANTIS_RECOMMEND = { property: '53422cdc8e92f89afbf09d5f', render: 'mantis__recommended__wordpress' }; var z = document.createElement("script"); z.type = "text/javascript"; z.async = true; z.src = "//static.mantis.marketing/recommend.min.js"; var s = document.getElementsByTagName('head')[0]; s.parentNode.insertBefore(z, s); …
What is the Endocannabinoid System?
An Endogenous Cannabinoid System (ECS), commonly referred to as an “Endocannabinoid System,” is found in every animal and regulates a broad range of biological functions. The ECS is a biochemical control system of neuromodulatory lipids (molecules that include fats, waxes, sterols and fat-soluble vitamins such as vitamins A, D, E and K and others) and specialized receptors configured to accept certain cannabinoids. In general, a given receptor will accept only particular classes of compounds and will be unaffected by other compounds, just as a specific key is needed to open a lock. Click here to learn more MANTIS_RECOMMEND …